Tufts System Signaling Lab - Manipulating Inter-Species Biological Fields With Non Invasive Tech

Xiaocheng Jian, a professor of bio-nano electronics at Tufts University, came on my radar today. I saved the pages on wayback and took screen shots. The focus is on inter-organism electrical signaling using non-invasive technology with an emphasis on nano-electronics and micro-fluidics. @Stephers

I should note that Pierre Omidyar is a graduate of Tufts. They started getting infusions of Koch money in 2017. Koch is pushing modular nuclear tech and bioengineering at other schools like MIT.

Tufts is also tied to the Unitarian Church, and their history is linked to secular humanism, scientific religion, and social reform. It was the Unitarians who brought Yogananda to the US in the early 1920s. He stayed with a Rosicrucian dentist! Yogananda was neighbors with Luther Burbank.

Profile on Jiang from a Tufts publication speaking to his work in wastewater processing.


https://blogs.rsc.org/ew/2020/07/27/emerging-investigator-series-xiaocheng-jiang/?doing_wp_cron=1661860208.8069930076599121093750

Below are screenshots and wayback links. There’s not a huge amount of content, so I would suggest looking it over to get an overview of this space. Biomaterials and water engineering and the interface of living and non-living “filters” seems significant.

System Signalling Lab

Living Electronics and Functional Microfluidics

Courses

Researchers


Publications


Facilities

News


2 Likes

@AMcD Ah, yes, I had found him here (only superficially speaking) — when I was digging around in September 2020 – with Charles Lieber, of course (search alphabetically):

https://cml.harvard.edu/people/former-group-members/


Jiang, Xiaocheng Assistant Professor Tufts University
Department of Biomedical Engineering

1 Like

And this guy at Tufts – Qiaobing Xu:

https://sites.tufts.edu/qxu/

Qiaobing Xu Inducted into Medical and Biological Engineering Elite (March 2020)

https://facultyprofiles.tufts.edu/qiaobing-xu/publications

With the emerging advances in utilizing nanocarriers for biomedical applications, a molecular-level understanding of the in vivo fate of nanocarriers is necessary. After administration into human fluids, nanocarriers can attract proteins onto their surfaces, forming an assembled adsorption layer called protein corona (PC). The formed PC can influence the physicochemical properties and subsequently determine nanocarriers’ biological behaviors. Therefore, an in-depth understanding of the features and effects of the PC on the nanocarriers’ surface is the first and most important step towards controlling their in vivo fate. This review introduces fundamental knowledge such as the definition, formation, composition, conformation, and characterization of the PC, emphasizing the in vivo environmental factors that control the PC formation. The effect of PC on the physicochemical properties and thus biological behaviors of nanocarriers was then presented and thoroughly discussed. Finally, we proposed the design strategies available for engineering PC onto nanocarriers to manipulate them with the desired surface properties and achieve the best biomedical outcomes.

The nanoparticles interact with the biomaterials in biological fluids, resulting in protein corona formation that may influence their properties and in vivo fate. The design strategies of drug delivery systems have been expanded due to the better understanding of protein corona composition and the interaction between nanoparticles and proteins.

Engineering a Nano/Biointerface for Cell and Organ-Selective Drug Delivery (July 2022)

https://pubs.acs.org/doi/10.1021/acs.langmuir.2c01609

1 Like


https://engineering.tufts.edu/bme/people/faculty/fiorenzo-omenetto

https://ase.tufts.edu/biomedical/unolab/Fio.html

Fiorenzo G. Omenetto is the Frank C. Doble Professor of Engineering, and a Professor of Biomedical Engineering at Tufts University. He also holds appointments in the Department of Physics and the Department of Electrical Engineering.

His research interests are at the interface of technology, biologically inspired materials and the natural sciences with an emphasis on new transformative approaches for sustainable materials for high-technology applications. He also serves as Dean for Research for the School of Engineering.

He has proposed and pioneered the use of silk as a material platform for advanced technology with uses in photonics, optoelectronics and nanotechnology applications, is co-inventor on several disclosures (~100) on the subject, and is actively investigating applications of this technology base both for technical and design applications.

Prof. Omenetto was formerly a J. Robert Oppenheimer Fellow at Los Alamos National Laboratories, a Guggenheim Fellow, and a Tällberg Foundation Global Leader. He is a Fellow of the Optical Society of America and of the American Physical Society, and a Senior Member of SPIE. He was named one of the 50 top people in tech by Fortune magazine in a class including (among others) Steve Jobs, Jeff Bezos, Larry Page, Shigeru Miyamoto. His research has been featured extensively in the press with coverage in the most important media outlets worldwide.

https://ase.tufts.edu/biomedical/unolab/people.html

A new route for silk | Nature Photonics (November 2008)

Famous for its use in clothing since early times, silk is now finding a new application as a useful biocompatible material in photonic devices. Thin films, diffraction gratings and organic photonic crystals are just a few of the exciting possibilities.

The growing demand for optical interfaces and sensors for biomedical applications is motivating research towards realizing biocompatible photonic components that offer a seamless interface between the optical and biological worlds. Silk — a natural protein fibre — has recently emerged as a highly promising candidate owing to its excellent mechanical and optical properties, biocompatibility, biodegradability and implant ability.

WATERPROOF STRETCHABLE OPTOELECTRONICS

(71) Applicants:THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS,

Urbana,IL (US); TRUSTEES OF TUFTS COLLEGE, Medford,MA (US)

(72) Inventors: JohnA.ROGERS, Wilmete,IL (US); Rak-Hwan KIM ,Champaign,IL (US);

Dae-Hyeong KIM , Urbana,IL (US);

David L.KAPLAN, Concord,MA (US); *Fiorenzo G. OMENETTO ,

Wakefield,MA (US)

1 Like

–Noticed C.M. Lieber on many of Jiang’s citations.

…”Lieber has published over 400 papers in peer-reviewed journals and is the principal inventor on more than 50 patents. In his spare time, Lieber has been active in commercializing nanotechnology, and founded the nanotechnology company Nanosys, Inc. in 2001 and the new nanosensor company Vista Therapeutics in 2007.”

Harvard chemistry chief’s arrest over China links shocks researchers

[Feb 2020]

“Researchers have reacted with shock to the arrest of Charles Lieber, a prominent Harvard University chemist and nanotechnology pioneer, who has been charged with making false statements to the US government about receiving research funding from China.

“Lieber, who is known for engineering new nanomaterials and developing their applications in medicine and biology, was arrested on 28 January. Two days later, a federal judge approved his release on cash bail of US$1 million.

“The charges focus on Lieber’s alleged involvement in China’s Thousand Talents Plan, a prestigious programme designed to recruit leading academics to the country. Documents outlining the charges allege that Lieber received hundreds of thousands of dollars from the Wuhan University of Technology (WUT) in China and agreed to lead a lab there — and that when US government agencies asked about his involvement with the programme he stated that he was not a participant and denied any formal affiliation with WUT. Lieber’s legal team did not respond to Nature’s requests for comment…

“His work, which has included the development of nanometre-diameter wires that can be used as sensors, has won him top awards, among them the 2017 NIH Director’s Pioneer Award and the 2012 Wolf Prize in Chemistry. In 2008, he was tipped by Thomson Reuters as a potential Nobel prizewinner.

“ ‘Charlie is the purest scientific scholar I have ever seen and personally I have 100% trust and confidence in him. I think there must be some misunderstanding during the handling of the case,’ says Xiaocheng Jiang, a former student of Lieber’s who is now a biomedical engineer at Tufts University in Medford, Massachusetts…

“A spokesperson for the National Institutes of Health (NIH) — from which Lieber also received funds — referred Nature’s queries to the FBI, citing an ongoing investigation…

“Details of Lieber’s alleged offences appear in a charging document submitted by the FBI in connection with his arrest. It says… Lieber agreed to be paid a salary of $50,000 per month, as well as about $150,000 a year in personal and living expenses, by WUT, and was given more than $1.5 million to set up a research lab there. According to a contract cited in the document, Lieber was to work at or for WUT for at least nine months a year. Lieber also agreed to host visiting scientists for two-month stints at his US lab, according to the FBI, an agreement that Harvard was not aware of.

…”China’s Thousand Talents Plan has been one focus of the US government’s efforts to crack down on foreign interference in research. In November last year, a US Senate panel suggested that the programme could be a means by which the Chinese government diverts US intellectual property for the state’s own benefit. Michael Lauer, a deputy director at the NIH, told lawmakers that the contracts encouraged participants to set up ‘shadow labs’ in China that replicated their work at US institutions. In December, an elite science advisory group known as JASON recommended in a report that US agencies support fruitful international collaborations while strengthening policies that require scientists to be transparent about conflicts of interest.

…”Lieber is not the first US scientist to become embroiled in ongoing political tensions between the United States and China. Last month, a former scientist at Los Alamos National Laboratory in New Mexico, who was accused of applying to and being recruited by the Thousand Talents Plan, pleaded guilty to making a false statement to the US government. And the Moffitt Cancer Center in Tampa, Florida, recently reported that six employees, including the chief executive, were forced to resign over failing to disclose their connection to the programme.”

https://www.nature.com/articles/d41586-020-00291-2

The trick with this is that Lieber had been working Mitre on nano since the early 1990s. I think the China story was meant to take attention away from that. Mitre was a sponsor of Lieber lab. His influence was far reaching.

https://cml.harvard.edu/people/former-group-members/

1 Like